Energy Center

Miroslav Sedlak

Contact Information

POTR 236
Laboratory of Renewable Research Engineering
College of Agriculture
West Lafayette, IN 47907


My research is focused on improving the ability of Saccharomyces cerevisiae to efficiently and economically produce bio-fuels and chemicals from renewable resources. I use systems biology and metabolic engineering approaches to achieve this goal. Specific examples of research in this area include metabolic engineering for novel or more efficient utilization of sugars from lignocellulosic materials, characterization of inhibitory effect of lignocellulosic hydrolysates on glucose/xylose co-fermentation as well as improving HXT transporters for xylose transport in yeast. I use system biology approach (expression profiling, proteomics, metabolomics). Another current research project is on establishing a metabolic pathway for the conversion of arabinose to ethanol by S. cerevisiae. I am also interested in characterization of effect of environmental stress on yeast physiology.  

Expertise: Ethanol fermentation, metabolic engineering, pathway engineering and sugar transport in Saccharomyces cerevisiae.



Degrees: M.S. - Bioengineering and Fermentation Technology, Institute of Chemical Technology, Prague, Czech Republic, 1986 Ph.D.-Molecular Microbiology, Academy of Science Institute of Microbiology in Prague, Czech Republic, 1993


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