Wei Zheng
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Contact Information Email: wz18@purdue.edu Office: CIVL 1169A Map Phone: (765) 496-6447 Fax: (765) 496-1377 Homepage: Homepage |
Head, School of Health Sciences, College of Health and Human Sciences Professor of Health Sciences and Toxicology  PubMed Listing  Google Scholar Listing  View Vita
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Education
PhD University of Arizona Pharmacology & Toxicology 1991
Research Interests
Toxicology of blood-brain barrier and blood-CSF barrier. Neurotoxicology of heavy metals (lead, manganese, iron, aluminum, and mercury): transport, homeostasis in the CNS, and molecular mechanisms. Roles of brain barriers in etiology of neurodegenerative diseases such as Parkinson's syndrome and Alzheimer's disease. Chelation therapy of metal toxicities. Transport of substances by the blood-CSF barrier in the choroid plexus. In vitro model of blood-brain/CSF barrier.
Teaching Interests
HSCI 101 Introduction to the Health Sciences Professions
Grants
2021 - National Institutes of Health/National Institute of Neurological Disorders and Stroke
2020 - National Institutes of Health/National Institute of Environmental Health Sciences
2020 - National Institutes of Health/National Institute on Aging
2020 - National Institutes of Health/National Institute of Environmental Health Sciences
2019 - Yale University
2019 - National Institutes of Health/National Institute of Environmental Health Sciences
2019 - Purdue Agricultural Science and Extension for Economic Development (AgSEED)
Selected Publications
Gu HY, Xu YD, Du N, Yu YQ, Zheng W and Du YS (2022). Lead (Pb) induced monocyte chemoattractant protein-1 in the choroid plexus. Biology 2022; 11(2):308. (IF:5.079) DOI:10.3390/biology11020308.
Adamson SF, Zheng W, Agim ZS, Du S, Fleming S, Shannahan J, and Cannon J (2021). Systemic copper disorders influence the olfactory function in adult rats: Roles of altered adult neurogenesis and neurochemical imbalance. Biomolecules 11(9):1315. (IF: 4.879) (PMCID: PMC8471899)
Liu L, Zheng W and Zhang YS (2021). Age-dependent decline of copper clearance at the blood-cerebrospinal fluid barrier in rats. Neurotoxicology 88:44-56. (IF:4.294) (PMCID: PMC8748412)
Chen HH, Li XL, Ma H, Zheng W, and Shen XL, (2021). Reduction in nesfatin-1 levels in the cerebrospinal fluid and increased nigrostriatal degeneration following ventricular administration of anti-nesfatin-1 antibody in mice. Front. Neurosci. 15:621173 IF:3.707. doi: 10.3389/fnins.2021.621173
Gaire S, Zheng W, Scharf ME and Gondhalekar AD (2021). Plant essential oil constituents synergize deltamethrin toxicity in a resistant strain of bed bugs (Cimex lectularius L.) by inhibiting cytochrome P450 enzymes. Pesticide Biochem Physiol 175:104829 (IF:3.680) DOI: 10.1016/j.pestbp.2021.104829.
Wang XX, Chen HH, Ma H, Zheng W and Shen XL (2021). Threshold effects of total copper intake on cognitive function in U.S. older adults and the moderating effect of fat and saturated fatty acid intake. J Academy of Nutrition and Dietetics 121(12):2429-2442. (IF:4.910) (PMID: 34219046)
Webb A, Spiers K, Falkenberg G, Gu HY, Dwibhashyam SS, Du YS, Zheng W and Nie LH (2021). Distribution of lead (Pb) and selenium (Se) in mouse brain following subchronic Pb exposure by using synchrotron X-ray fluorescence. Neurotoxicology 88:106-115. (PMCID: PMC8748384)
Rolle-McFarland D, Liu Y, Mostafaei F, Zauber SE, Zhou Y, Li Y, Fang Q, Zheng W, Nie LH and Wells E (2021). The association of bone and blood manganese with motor function in Chinese workers. Neurotoxicology 88:224-230. (PMCID: PMC8748420)
Zheng W and Ghersi-Egea, JF (2020). Brain barrier systems play no small roles in toxicant-induced brain diseases and disorders. Toxicol Sci 175(2):147-148. IF:4.081 (PMCID: PMC7253204).
Zheng W (2020). Systemic impact of trace elements on human health and disease: Nutrition, toxicity, and beyond (Editorial). J Trace Elem Med Biol 62:126634. IF:3.245. (PMCID: PMC7781149)