Jennifer L. Freeman
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Contact Information Email: jfreema@purdue.edu Office: HAMP-1163D Map Phone: 765-494-1408 Fax: 765-496-1377 Homepage: Homepage |
Professor of Toxicology PubMed Listing  Google Scholar Listing  View Vita
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Education
PhD University of Illinois at Urbana-Champaign Enviromental Toxicology and Molecular Cytogenetics 2005
Research Interests
Genetic and epigenetic mechanisms of toxicity of the developmental origin of adult disease from low dose exposure to environmental chemicals
Teaching Interests
Toxicology and Environmental Health
Grants
2022 - Indo-US SERB
2021 - Indo-US SERB
2021 - National Institute of Environmental Health Sciences
2021 - Purdue Institute for Drug Discovery and Integrative Neuroscience Alzheimer's Disease and other Dementias
2020 - Purdue Agricultural Science and Extension for Economic Development (AgSEED)
2020 - National Institute of Environmental Health Sciences
2020 - Purdue Research Foundation
2019 - National Institute for Occupational Safety and Health, Occupational and Environmental Health and Safety Education and Research Center, University of Illinois at Chicago
2019 - National Institute for Occupational Safety and Health, Occupational and Environmental Health and Safety Education and Research Center, University of Cincinnati
2019 - Purdue Big Idea Challenge 2.0
2019 - Indo-US SERB
Selected Publications
Sanchez, O.F., L.F. Lin, J. Xie, J.L. Freeman, and C. Yuan. 2022. Lead Exposure Induces Dysregulation of Constitutive Heterochromatin Hallmarks in Live Cells. Current Res. Toxicol.3:100061. https://doi.org/10.1016/j.crtox.2021.12.001
Kiper, K. and J.L. Freeman. 2022. Use of Zebrafish Genetic Models to Study Etiology of the Amyloid-Beta and Neurofibrillary Tangle Pathways in Alzheimer's Disease. Current Neuropharmacology. DOI : 10.2174/1570159X19666210524155944 (invited review)
Lin, L., J. Xie, O.F. Sanchez, C. Bryan, J.L. Freeman, and C. Yuan. 2021. Low dose lead exposure induces alterations on heterochromatin hallmarks persisting through SH-SY5Y cell differentiation. Chemosphere. 264:128486.
Horzmann, K.A., L.F. Lin, B. Taslakjian, C. Yuan, and J.L. Freeman. 2021. Embryonic atrazine exposure and later in life behavioral and brain transcriptomic, epigenetic, and pathological alterations in adult male zebrafish. Cell Biol. Toxicol. 37(3):421-439. DOI: 10.1007/s10565-020-09548-y.
Wasel, O., K.M. Thompson, Y. Gao, A.E. Godfrey, J. Gao, C. Mahaptra, L.S. Lee, M.S. Seplveda, and J.L. Freeman. 2021. Comparison of zebrafish in vitro and in vivo developmental toxicity assessments of perfluoroalkyl acids (PFAAs). J. Toxicol. and Environ. Health Part A. 84(3):125-136. https://doi.org/10.1080/15287394.2020.1842272 (IF: 2.649)
Xie, J., L. Lin, O. Sanchez, C. Bryan, J.L. Freeman, and C. Yuan. 2021. Pre-differentiation exposure to low-dose of atrazine results in persistent phenotypic changes in human neuronal cell lines. Environ. Pollution. 271:116379. DOI: 10.1016/j.envpol.2020.116379
Ahkin Chin Tai, J.,K.A. Horzmann, J. Franco, A.S. Jannasch, B.R. Cooper, and J.L. Freeman. 2021. Developmental atrazine exposure in zebrafish produces the same major metabolites as mammals along with altered behavioral outcomes. Neurotoxicology and Teratology. 85: 106971. https://doi.org/10.1016/j.ntt.2021.106971
Stradtman, S. and J.L. Freeman. 2021. Mechanisms of neurotoxicity associated with exposure to the herbicide atrazine. Toxics. 9:207. (invited review)
Wasel, O. and J.L. Freeman. 2020. Chemical and genetic zebrafish models to define mechanisms of and treatments for dopaminergic neurodegeneration. International Journal of Molecular Sciences. 21(17):5981. https://doi.org/10.3390/ijms21175981 (invited review)
Lee, J. and J.L. Freeman. 2020. Exposure to the heavy metal lead induces DNA copy number alterations in zebrafish cells. Chem. Res. Toxicol. 33:2047-2053. doi: 10.1021/acs.chemrestox.0c00156.