Ranjie Xu
 |
Contact Information Email: xu1726@purdue.edu Office: LYNN G193C Map Phone: 765-496-4007 Homepage: Homepage |
Assistant Professor, Department of Basic Medical Sciences Google Scholar Listing  View Vita
|
Education
PhD University of Science and Technology of China Neuroscience 2015
Research Interests
The Xu laboratory works on developing human stem cell models to study the underlying mechanisms of human neurological disorders, such as Alzheimer's disease, and apply these models for drug screening. To achieve this, we have developed human stem cell-based 3D in vitro brain organoids and human-mouse chimeric brain models to investigate human neurons, microglia, and neuro-immune interactions in neurological disorders. Furthermore, we are working on engineering human stem cell-derived neural and immune cells, with the aim of creating innovative cell therapies to treat neurological disorders.
Teaching Interests
Neuroscience, stem cell
Grants
2024 - National Institute on Aging
2024 - National Institute of Neurological Disorders and Stroke
2024 - CTSI Alzheimer's Disease Pre-Clinical Translational Science Grant
2024 - Purdue Institute for Integrative Neuroscience
2023 - CTSI Women's Health
2023 - Purdue University Showalter Trust
2023 - Purdue Institute for Integrative Neuroscience (2)
2022 - Purdue Institute for Integrative Neuroscience
Selected Publications
Ji, Y., Chen, X., Joseph, M.C., McLean, J.L., Yang, Y., Yuan, C., Rochet, J.C., Liu, Fei., and Xu, R. (2024). Alzheimer's disease patient brain extracts induce multiple pathologies in vascularized neuroimmune organoids for disease modeling and drug discovery. bioRxiv link https://www.biorxiv.org/content/10.1101/2024.10.28.620680v1
Ji, Y., McLean, J.L., Xu, R. (2024). Emerging Human PSC-based Human-Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders. Neuroscience Bulletin 1-18.
Xu, R., Boreland, A.J., Li, X., Erickson, C., Jin, M., Atkins, C., Pang, Z.P., Daniels, B.P., and Jiang, P. (2021). Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology. Stem Cell Reports 16, 1923-1937. (# co-corresponding author)
Jiang, P., Turkalj, L., Xu, R. (2020). High-fidelity modeling of human microglia with pluripotent stem cells. Cell Stem Cell 26 (5), 629-631
Xu, R., X, Li., Boreland, A., Posyton, A., Kwan, K., Hart, R.P., and Jiang, P. (2020). Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain. Nature Communications 11 (1), 1-16
Xu, R., Brawner, A., Li, S., Kim, H., Xue, H., Pang, Z., Kim, W.-Y., Hart, R., Liu, Y., and Jiang, P. (2019). OLIG2 drives abnormal neurodevelopmental phenotypes in human iPSC-based organoid and chimeric mouse models of Down syndrome. Cell Stem Cell 24 (6), 908-926. e8