Jason Cannon

Jason Cannon Profile Picture

Associate Professor of Toxicology
Ph.D., Toxicology, University of Michigan

Contact Info:

cannon6@purdue.edu
765-494-0794
DLR
https://www.purdue.edu/hhs/hsci/directory/faculty/cannon_jason.html
 

Training Group(s):
Integrative Neuroscience

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

We are a neurotoxicology laboratory focused on identifying mechanisms adverse neurological and mental health outcomes resulting from environmental exposures. We have primarily focused on Parkinson’s disease, but are also interested in overlapping pathways between other neurological diseases and mental health disorders. We aim to use our mechanistic neurotoxicology data to identify exposures that should be reduced and also to test new therapeutic targets. We are particularly interested in pathogenic interactions between genetic factors and environmental insults. Ongoing projects are primarily focused on the neurotoxicity of 1) heterocyclic amines, which are formed during high temperature meat cooking and; 2) per- and polyfluoroalkyl substances (PFAS), synthetic compounds found in the blood of nearly all humans. Mechanistic studies examine the pathogenic pathways that underlie neurotoxicity. The major techniques utilized in the lab are neurobehavioral analysis, neurochemistry (HPLC w/electrochemical detection) and histopathology/microscopy using a variety of in vitro and in vivo systems.

Selected Publications:

Lawana, V., Um, S. Y., Rochet, J. C., Turesky, R. J., Shannahan, J. H., and Cannon, J. R. (2020). Neuromelanin Modulates Heterocyclic Aromatic Amine-Induced Dopaminergic Neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology 173(1), 171-188.

Sammi, S. R., Foguth, R. M., Nieves, C. S., De Perre, C., Wipf, P., McMurray, C. T., Lee, L. S., and Cannon, J. R. (2019). Perfluorooctane Sulfonate (PFOS) Produces Dopaminergic Neuropathology in Caenorhabditis elegans. Toxicological sciences : an official journal of the Society of Toxicology 172(2), 417-434, 10.1093/toxsci/kfz191.

Foguth, R. M., Flynn, R. W., de Perre, C., Iacchetta, M., Lee, L. S., Sepulveda, M. S., and Cannon, J. R. (2019). Developmental exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) selectively decreases brain dopamine levels in Northern leopard frogs. Toxicology and applied pharmacology 377, 114623, 10.1016/j.taap.2019.114623.

Wise, J. P., Jr., Price, C. G., Amaro, J. A., and Cannon, J. R. (2018). Autophagy Disruptions Associated With Altered Optineurin Expression in Extranigral Regions in a Rotenone Model of Parkinson's Disease. Front Neurosci 12, 289, 10.3389/fnins.2018.00289.

Cruz-Hernandez, A., Agim, Z. S., Montenegro, P. C., McCabe, G. P., Rochet, J. C., and Cannon, J. R. (2018). Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons. Neurotoxicology 65, 68-84, 10.1016/j.neuro.2018.01.009.

Agim, Z. S., and Cannon, J. R. (2018). Alterations in the nigrostriatal dopamine system after acute systemic PhIP exposure. Toxicology letters 287, 31-41, 10.1016/j.toxlet.2018.01.017. Full citation list: http://scholar.google.com/citations?user=l3f_ixcAAAAJ&hl=en

Wise, J. P., Jr., Price, C. G., Amaro, J. A., and Cannon, J. R. (2018). Autophagy Disruptions Associated With Altered Optineurin Expression in Extranigral Regions in a Rotenone Model of Parkinson's Disease. Front Neurosci 12, 289, 10.3389/fnins.2018.00289.

Cruz-Hernandez, A., Agim, Z. S., Montenegro, P. C., McCabe, G. P., Rochet, J. C., and Cannon, J. R. (2018). Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons. Neurotoxicology 65, 68-84, 10.1016/j.neuro.2018.01.009.

Agim, Z. S., and Cannon, J. R. (2018). Alterations in the nigrostriatal dopamine system after acute systemic PhIP exposure. Toxicology letters 287, 31-41, 10.1016/j.toxlet.2018.01.017.

Sammi, S. R., Agim, Z. S., and Cannon, J. R. (2018). From the Cover: Harmane-Induced Selective Dopaminergic Neurotoxicity in Caenorhabditis elegans. Toxicological sciences : an official journal of the Society of Toxicology 161(2), 335-348, 10.1093/toxsci/kfx223.

Wise, J. P., Jr., and Cannon, J. (2016). From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models. Toxicological sciences : an official journal of the Society of Toxicology 153(2), 372-81, 10.1093/toxsci/kfw133.

Lee, J. W., Tapias, V., Di Maio, R., Greenamyre, J. T., and Cannon, J. R. (2015). Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats. Neurobiology of aging 36(1), 505-18, 10.1016/j.neurobiolaging.2014.07.011.

Full citation list: http://scholar.google.com/citations?user=l3f_ixcAAAAJ&hl=en 

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