Jayant Krishna

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

We are interested in elucidating the fundamental biophysical mechanisms by which single neurons process and integrate information, and how these features influence and decide population coding, plasticity, and sensory input processing in the brain. To this end, we focus on the computational role that synapses and dendrites play in deciding and influencing the overall input-output transfer function of a neuron. There is growing evidence to suggest that the location and interplay between synapses, local dendritic electrical features, spatial arrangement of specific membrane channels, and local biophysical properties strongly influence local and global computations (Ex: dendritic spiking, co-incidence detection, electrical compartmentalization, biochemical compartmentalization, and simple logic functions). Yet, exactly how these multiple integrative effects influence overall circuit output and create a stable behavioral response is still unknown. We seek to develop new tools and techniques, and in conjunction with cutting-edge two-photon imaging and nanoscale electrophysiology tease apart these fundamental biophysical mechanisms through which single neurons and small populations of neurons process and shape information

Selected Publications:

Krishna Jayant, Michael Wenzel, Yuki Bando, Jordan Hamm, Nicola Mandriota, Jake H. Rabinowitz, Ilan J-L Plante, Jonathan Owen, Ozgur Sahin, Kenneth L. Shepard and Rafael Yuste, “Flexible nanopipettes for minimally-invasive intracellular electrophysiology in vivo “, Cell Reports, vol 26, 1, pages 266-278, 2019

Krishna Jayant, Jan J. Hirtz, Ilan Jen‐La Plante , David M. Tsai ,Wieteke D.A.M De Boer, Alexa Semonche, Darcy S. Peterka, Jonathan S. Owen, Ozgur Sahin, Kenneth L. Shepard and Rafael Yuste ʺTargeted intracellular voltage recordings from dendritic spines using quantumdot coated nanopipettesʺ, Nature Nanotechnology, vol. 12, pages 335–342, 2017

Krishna Jayant, Amit Singhai, Joshua B.Phelps, Yingqiu Cao, Manfred Lindau, David A. Holowka, Barbara A. Baird and Edwin C. Kan, “Non‐Faradaic Electrochemical Detection of Exocytosis from Mast and Chromaffin Cells Using CMOS Floating Gate Transistors”, Scientific Reports, 5, 18477, 2015

Krishna Jayant, Kshitij Auluck, Mary Funke, Sharlin Anwar, Joshua B. Phelps, Phillip H. Gordon, Shantanu R. Rajwade and Edwin C.Kan, “Programmable Ion Sensitive Transistor (ISFET) Interfaces I. Electrochemical Gating”, Phys. Rev. E 88, 012801, 2013