Rong Huang

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Our lab applies a multidisciplinary approach to 1.) Elucidate the mechanisms and functions of epigenetic modifications including methylation and acetylation; 2.) Rational design and synthesize selective and potent inhibitors for methyltransferases and acetyltransferases; 3.) Develop novel therapeutic agents for cancer and other diseases through targeting epigenetic pathways.

Selected Publications:

Diaz K, Meng Y, Huang R. (2021) Past, present, and perspectives of protein N-terminal methylation. Current Opinion in Chemical Biology. 63, 115-122. PMID: 33839647. authors.elsevier.com/a/1ct4q4sz6MBAlF Chen D, Dong G, Deng Y, Noinaj N, Huang R. (2021)

Structure-based Discovery of Cell-potent Peptidomimetic Inhibitors for Protein N-terminal Methyltransferase 1. ACS Medicinal Chemistry Letters. 12, 485-493. PMID: 33738076; PMCID:PMC7958150. pubs.acs.org/doi/full/10.1021/acsmedchemlett.1c00012 ​ Ho Y, Chen L, Huang R. (2021)

Development of a continuous fluorescence-based assay for N-terminal acetyltransferase D. International Journal of Molecular Sciences. 22, 594. PMID: 33435607; PMCID:PMC7827481. www.mdpi.com/1422-0067/22/2/594 Al-Hamashi AA, Chen D, Deng Y, Dong G, Huang R. (2020)

Discovery of a Potent and Dual-Selective Bisubstrate Inhibitor for Protein Arginine Methyltransferase 4/5. Acta Pharmaceutica Sinica B. in press. ​www.sciencedirect.com/science/article/pii/S2211383520307656 Mackie BD, Chen D, Dong G, Dong C, Parker H, Schaner Tooley C, Noinaj N, Min J, Huang R. (2020)

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational design, synthesis, characterization, and crystallographic studies. Journal of Medicinal Chemistry. 63, 9512-9522. PMID: 32689795. PMCID: PMC74286280. https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00689 Chen D, Dong C, Dong G, Srinivasan K, Min J, Noinaj N, Huang R. (2020)

Probing the plasticity in the active site of protein N-terminal methyltransferase 1 using bisubstrate analogs. Journal of Medicinal Chemistry. 63, 8419-8431. PMID: 32605369. PMCID: PMC7429357. https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00770