Funding Opportunities

Notices of Special Interest (NOSI): High Priority Areas in Integrative Neuroscience Branch in the Division of Neuroscience and Behavior

Deadline: January 08, 2026
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The mission of the Division of Neuroscience and Behavior (DNB) is to facilitate and promote outstanding basic animal and human research aimed at identifying the causes and consequences of substance use and substance use disorders (SUD) across the lifespan and to guide treatment strategies. The Integrative Neuroscience (IN) Branch within DNB supports research on the cellular mechanisms and circuitry that underlie substance use and SUD. Research supported by the Branch covers: 1) the regulation and plasticity of neurotransmitter and neuromoduatory systems induced by chronic or intermittent exposure to, and/or withdrawal from, addictive substances, 2) the study of substance-induced neurotoxicity, 3) neuron-glia interactions and their modification by substance use and SUD 4) neuroendocrine modulation of neural systems in relation to substance use and SUD , and 5) neuroimmune modulation of the brain including the influences of neuroAIDS and substance-induced neuroinflammation.

Notice of Special Interest (NOSI): Halting Tuberculosis (TB) Transmission

Deadline: January 08, 2026
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The purpose of this Notice of Special Interest (NOSI) is to highlight NIAID’s interest in accepting applications that aim to understand the critical drivers of Tuberculosis (TB) transmission at the individual and population levels in high-burden settings. Applicants are encouraged to develop effective methods to measure rates of TB transmission that rely on an increased understanding of the biomedical basis of transmission and related risk factors and to develop and assess potential interventions, including low-cost and low-tech options, to prevent TB transmission.

Notice of Special Interest (NOSI): Targeting the Pathogen within the Arthropod Vector

Deadline: January 08, 2026
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This Notice of Special Interest (NOSI) invites applications to stimulate multidisciplinary research to better understand pathogen/vector interactions to identify approaches to prevent pathogen transmission to the vertebrate host.

NLM Research Grants in Biomedical Informatics and Data Science (R01 Clinical Trial Optional)

Deadline: January 08, 2026
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The National Library of Medicine (NLM) supports innovative research and development in biomedical informatics and data science. This funding opportunity focuses on biomedical discovery and data-powered health, integrating streams of complex and interconnected research outputs that can be translated into scientific insights, clinical care, public health practices, and personal wellness. The scope of NLM's interest in these research domains is broad, with emphasis on new and innovative methods and approaches to foster data driven discovery in the biomedical and clinical health sciences as well as domain-independent, scalable, and reusable/reproducible approaches to discovery, curation, analysis, organization, and management of health-related digital objects.

Engineering Next-Generation Human Nervous System Microphysiological Systems (R01 Clinical Trials Not Allowed)

Deadline: January 08, 2026
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This Funding Opportunity Announcement (FOA) encourages research grant applications directed toward developing next-generation human cell-derived microphysiological systems (MPS) and related assays that replicate complex nervous system architectures and physiology with improved fidelity over current capabilities. Supported projects will be expected to enable future studies of complex nervous system development, function, and aging in healthy and disease states.

This FOA is intended to encourage the further development of projects with feasibility support for the line of investigation. Applicants proposing exploratory research at the early and conceptual stages of project development may instead wish to apply to the companion R21 FOA (PAR-23-047).

Engineering Next-Generation Human Nervous System Microphysiological Systems (R01 Clinical Trials Not Allowed)

Deadline: January 08, 2026
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Notice of Special Interest (NOSI): Advancing Development of Rapid Point-of-Care Hepatitis C Virus Diagnostics

Deadline: January 08, 2026
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Infection rates of hepatitis C virus (HCV) in the United States of America (USA) have steadily risen since 2010. There are approximately 2 million people infected with HCV in the USA with up to 140,000 new infections occurring annually. Globally, there are an estimated 71 million people living with HCV and it is estimated that as many as 50% may be unaware of their infection.

The World Health Organization’s (WHO) goals for eliminating HCV infection by 2030 will require better case identification/diagnosis and linkage to care. A point-of-care diagnostic that is accurate, simple, rapid, and affordable will greatly increase the diagnoses of HCV infections and link those infected to care. The current process to diagnose an active infection with HCV requires at least two tests and can take up to one week for results. An initial point-of-care screen for HCV antibodies in blood is followed, if positive, by a viral load test performed in a centralized laboratory. Either the same sample is reflex tested, or the patient must supply an additional sample. One-step testing for active HCV infections utilizing a point-of-care assay would allow patients to receive their result in a single visit and allow for rapid care planning and management.

Notice of Special Interest (NOSI): Research Opportunities Centering the Health of Women Across the HIV Research Continuum

Deadline: January 08, 2026
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The NIH Office of Research on Women’s Health (ORWH) and Office of AIDS Research (OAR), in partnership with our Institute, Center, and Office (ICO) partners are issuing this Notice to highlight interest in receiving HIV research and training grant applications that explicitly and intersectionally center the health needs of cisgender women and girls, and gender-diverse people.

Despite tremendous scientific advances that have translated to substantial progress in confronting the HIV epidemic, women – and particularly women of color, young women and girls, and transgender women – and gender-diverse individuals remain disproportionately affected by HIV. An intersectional, equity-informed, data-driven approach is essential to advance HIV research and clinical care for all women with or impacted by HIV across their lifespan and to end the HIV pandemic (Barr et al, 2024).

Notice of Special Interest (NOSI): Research Opportunities Centering the Health of Women Across the HIV Research Continuum

Deadline: January 08, 2026
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Notice of Special Interest (NOSI): Research Opportunities Centering the Health of Women Across the HIV Research Continuum

Deadline: January 08, 2026
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Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 - Clinical Trial Optional)

Deadline: January 08, 2026
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This initiative will support intervention research that addresses structural racism and discrimination (SRD) in order to improve minority health or reduce health disparities.

In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed)

Deadline: January 08, 2026
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The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to phenotype and/or perform research on embryonic lethal knockout (KO) mouse strains being generated through the International Mouse Phenotyping Consortium (IMPC) of which the NIH Knockout Mouse Phenotyping Program (KOMP2) is a member. The mission of IMPC is to generate a comprehensive catalogue of mammalian gene function that will provide the foundation for functional analyses of human genetic variation. The current (July 19, 2022) IMPC data release includes phenotypic data for 8260 knockout genes. Overall, the IMPC hopes to generate a null mutant and undertake broad-based phenotyping for every gene in the mouse genome. About 30% of these strains are expected to be either embryonic or perinatal lethal, or subviable. However, a large portion of homozygous lethal mutations are expected to have viable heterozygous phenotypes. The scientific community has the unique opportunity to leverage these mouse strains while they are being created and bred as part of the IMPC adult mouse phenotyping effort to perform additional in-depth phenotyping and research.

Implementation Research for Multi-morbidity Management in the Context of Non-communicable Diseases in Low- and Middle-Income Countries and US Tribal Populations (R01 Clinical Trial Optional)

Deadline: January 08, 2026
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The National Institutes of Health (NIH) participating Institutes, Centers, and Offices (ICOs), in collaboration with the Global Alliance for Chronic Diseases (GACD), invite applications for implementation research that aims to improve the availability of effective, equitable, efficient, integrated, patient-centered, safe, and timely care for people living with multiple long-term conditions (non-communicable disease (NCD) multimorbidity) in low- and middle-income countries (LMICs) and/or within American Indian/Alaska Native (AI/AN) populations in the United States. This Notice of Funding Opportunity (NOFO) supports innovative approaches to identifying, understanding, developing, and implementing strategies for overcoming barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based interventions, tools, policies, and guidelines. In addition, studies to advance dissemination and implementation research methods and measures into application are encouraged.

All applications must be within the scope of the mission of one of the Institutes/Centers listed above (see "Components of Participating Organizations," excluding the Fogarty International Center which manages this program but does not support awards). Applications will be accepted from US and World Bank-defined LMIC institutions only.

Notice of Special Interest (NOSI): Impact of Policy Interventions Aimed at Addressing Social Determinants of Health to Improve Functioning and Well-being for People with Serious Mental Illnesses

Deadline: January 09, 2026
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This Notice of Special Interest (NOSI) highlights research priorities on the impact of social and economic policy interventions that address social determinants of health (SDOH) on improvements in access and engagement with mental health treatment, mental health functioning, and quality of life for people with serious mental illnesses, with special attention to understanding the underlying mediators/change mechanisms of those policies on outcomes.

Understanding Expectancies in Cancer Symptom Management (R01 Clinical Trial Required)

Deadline: February 05, 2026
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This Notice of Funding Opportunity (NOFO) will solicit mechanistic research that aims to understand how and why expectancy effects occur in a cancer context, elucidate their role in cancer symptom management, and identify patients, symptoms, cancer sites, and contexts in which expectancy effects can be leveraged to improve cancer outcomes. Expectancies are defined in this context as beliefs about future outcomes, including one’s response to cancer or cancer treatment. Expectancies can be evoked by social, psychological, environmental, and systemic factors. Expectancy effects are the cognitive, behavioral, and biological outcomes caused by expectancies. Expectancy effects can be generated by expectancies held by patients, clinicians, family members, caregivers, and/or dyadic/social networks. Program is particularly interested in applications that enroll individuals and groups from populations historically underrepresented or excluded from biomedical and behavioral research.

Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R01 Clinical Trial Optional)

Deadline: February 05, 2026
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The purpose of this notice of funding opportunity (NOFO) is to support translational and clinical research to (1) advance precision medicine in pregnant women, lactating women, and children through the development of novel tools, models, and other technologies that could have a direct clinical or health impact; (2) enhance the understanding of the underlying mechanisms of drug action, including the role of pediatric ontogeny and the dynamic physiological changes that occur during pregnancy and lactation; and (3) discover and develop novel therapeutics or enhance the usage of existing drugs or drug repurposing for safer and more effective medications in pregnant and lactating women, neonates, and children. The overall goal is to improve safe and effective precision therapeutics for pregnant and lactating women, fetuses, neonates, and children, including those with disabilities.

Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21/R33 - Clinical Trial Optional)

Deadline: February 20, 2026
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The purpose of this Notice of Funding Opportunity (NOFO) is to encourage exploratory/developmental research applications that propose to study the development, validation, feasibility, and effectiveness of innovative mobile health (mHealth) interventions or tools specifically suited for low- and middle-income countries (LMICs) that utilize new or emerging technology, platforms, systems, and/or analytics. The overall goal of the program is to catalyze innovation through multidisciplinary research that addresses global health problems, develop an evidence base for the use of mHealth technology to improve clinical and public health outcomes, and strengthen mHealth research capacity in LMICs.

This FOA provides support for up to two years (R21 phase) for technology development and feasibility studies, followed by a possible transition to expanded research support (R33 phase) for validation, larger-scale feasibility, and effectiveness studies. Transition to the R33 depends on the completion of applicant-defined milestones, as well as program priorities and the availability of funds. All applicants must address both the R21 and R33 phases.

NLM Information Resource Grants to Reduce Health Disparities and Promote Health Equity (G08 Clinical Trial Not Allowed)

Deadline: April 24, 2026
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This Notice of Funding Opportunity Announcement (NOFO) solicits resource grant applications for projects that will provide accurate, useful, usable, and understandable health information to populations that experience health disparities and their health care providers. This NOFO supports the development of resources that can be used to improve health and well-being and that lead to reductions in health disparities. Access to accurate, useful, usable, and understandable health information is an important factor when managing health and health care. Proposed projects should harness the capabilities of information technology and medical or health libraries to disseminate clear, evidence-based health-related information in formats used by individuals and their health care providers. Proposed projects should emphasize the development and deployment of new information resources or services, or expand and improve an existing resource or service, to meet the needs of populations experiencing health disparities and to promote health equity.

NIH Brain Development Cohorts (NBDC) Biospecimen Access (X01 Clinical Trial Not Allowed)

Deadline: May 06, 2026
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The Adolescent Brain Cognitive DevelopmentSM (ABCD) Study is the largest longitudinal study of brain development and child health in the U.S., collecting data from more than 11,000 children across the country beginning when they were 9-10 years old and continuing for a decade. In addition to behavioral assessments, youth undergo neuroimaging and provide biospecimens, including oral fluids for hormone analysis, urine and hair for substance use and exposure, deciduous teeth for environmental exposures, and blood for genetic analysis and metabolic and hematologic assays.

This initiative allows investigators to apply for access to biological samples from the ABCD Study . More information about the ABCD Study can be found on the NIDA ABCD Study web page. Additional information about this resource is available on the NIDA funding opportunities page, under Supplemental Information for NOFOs. ABCD Study biospecimens are managed through the NIH Brain Development Cohorts (NBDC) Biorepository and Analysis Center, which offers a web portal with services related to biospecimen access. Visit the NBDC portal to query available samples using the Biospecimen Explorer, submit a Biospecimen Availability Inquiry to determine the resource availability and impact on existing samples, and learn more about this resource.

Multisite Clinical Research: Leveraging Network Infrastructure to Advance Research for Women, Children, Pregnant and Lactating Individuals, and Persons with Disabilities (U01 Clinical Trial Optional)

Deadline: May 08, 2026
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The purpose of this funding opportunity announcement (FOA) is to invite applications for multisite clinical trials and observational studies developed in conjunction with NICHD Networks that will be conducted using NICHD-supported Network infrastructure. The goal of this FOA is to operationalize the previously reported NICHD guiding principles for multisite clinical trials delineated in Notice NOT-HD-19-034:

To enhance the rigor and reproducibility of clinical trial protocols

To promote greater availability of multisite clinical trial infrastructure to support trials from a wider range of investigators

To facilitate data sharing and access to biospecimens to efficiently expand research capacity for all investigators

To facilitate greater involvement of diverse populations in multisite clinical trials.

Consequently, multisite clinical trials and observational studies conducted by and within the participating NICHD-supported Clinical Research Networks will be submitted as investigator-initiated, multi-Principal Investigator (PI) grant applications by any qualified investigator in the extramural community (including NICHD Network investigators) in conjunction with the respective NICHD Network Data Coordinating Center (DCC). It is the intent of this initiative to utilize the NICHD Clinical Research Network infrastructure in a manner that will promote the funding and support of the best science in a timely, transparent, equitable and cost-effective manner.

Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R01 Clinical Trial Optional)

Deadline: May 08, 2026
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The purpose of this notice of funding opportunity (NOFO) is to support translational and clinical research to (1) advance precision medicine in pregnant persons, lactating persons, and children through the development of novel tools, models, and other technologies that could have a direct clinical or health impact; (2) enhance the understanding of the underlying mechanisms of drug action, including the role of pediatric ontogeny and the dynamic physiological changes that occur during pregnancy and lactation; and (3) discover and develop novel therapeutics or enhance the usage of existing drugs or drug repurposing for safer and more effective medications in pregnant and lactating persons, neonates, and children. The overall goal is to improve safe and effective precision therapeutics for pregnant and lactating persons, fetuses, neonates, and children, including those with disabilities.

Notice of Special Interest in Research on Family Support and Rejection in the Health and Well-Being of SGM Populations

Deadline: May 08, 2026
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The mission of the NIH is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The NIH is committed to supporting research that will increase scientific understanding of health and well-being and lead to the development of effective evidence-based strategies, interventions, and services for people of all ages and backgrounds. NIH places a high priority on research with individuals and populations at increased risk for adverse health outcomes, and especially those who have received insufficient attention from the scientific research enterprise. To this end, and in response to Executive Order 14075 on Advancing Equality for Lesbian, Gay, Bisexual, Transgender, Queer, and Intersex Individuals, this Notice of Special Interest (NOSI) announces an interest in research on the impact and consequences of family support and family rejection on the health and well-being of sexual and gender minority (SGM, defined for NIH purposes in NOT-OD-19-139) individuals across the life course.

Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)

Deadline: May 08, 2026
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The National Institutes of Health (NIH) and the Centers for Disease Control and Prevention hereby notify Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) whose research is supported by specific types of research grants (activity codes listed above) that funds are available for administrative supplements to enhance the diversity of the research workforce by recruiting, mentoring, and supporting high school, undergraduate and graduate/clinical students, postbaccalaureate and post Masters individuals, postdoctoral researchers (including health professionals), and eligible investigators from diverse backgrounds, including those from groups that have been shown to be underrepresented in health-related research. This supplement opportunity is also available to support PD(s)/PI(s) of research grants who are or become disabled and need additional support to accommodate their disability in order to continue to work on the research project. The activities proposed in the supplement application must fall within the scope of the parent grant, and simultaneously advance the objectives of the parent grant and support the research training and professional development of the supplement candidate.

This Notice of Funding Opportunity (NOFO) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial. Applicants to this NOFO are permitted to propose research experience in a clinical trial led by a mentor or co-mentor.

Research With Activities Related to Diversity (ReWARD) (R01 Clinical Trial Optional)

Deadline: May 08, 2026
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The NIH Research With Activities Related to Diversity (ReWARD) Program's overarching goal is to enhance the breadth and geographical location of research and research-related activities supported by NIH. The ReWARD program provides support for the health-related research of scientists who are making a significant contribution to Diversity, Equity, Inclusion, and Accessibility (DEIA) and who have no current NIH research project grant funding. The ReWARD program provides funding for both the scientific research and the DEIA activities of investigators. The grant will support scientific research in areas related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) and ongoing DEIA activities focused on enhancing diversity in the biomedical research enterprise within the United States and territories.

Understanding Expectancies in Cancer Symptom Management (R01 Clinical Trial Required)

Deadline: May 08, 2026
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Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R01 Clinical Trial Optional)

Deadline: May 08, 2026
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Notice of Special Interest (NOSI): Research to Address Vaccine Uptake and Implementation among Populations Experiencing Health Disparities

Deadline: June 06, 2026
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This Notice of Special Interest (NOSI) highlights the need for research on strategies and interventions to increase vaccine uptake and implementation among populations experiencing health disparities in the United States (U.S.) and its territories. Research is needed to understand and address misinformation, uncertainty, distrust, and hesitancy regarding uptake of vaccines (e.g., SARS-CoV-2, pneumococcal, influenza, hepatitis B, human papilloma virus (HPV), varicella, tetanus, diphtheria, and pertussis [Tdap]) among individuals in the U.S. and its territories, especially in populations at increased risk for morbidity and mortality due to long-standing systemic health and social inequities, as well as chronic medical conditions. This NOSI is focused on individuals across the life span (i.e., all ages). The purpose of this NOSI is to solicit research that will: 1) understand and address barriers to increasing reach, access, and uptake of vaccinations among populations experiencing health disparities; 2) evaluate organizational, local, state, and federal policies and initiatives that mitigate or exacerbate disparities in vaccine access, uptake, and series completion, and 3) evaluate community-engaged interventions (e.g., expand reach, address psychosocial barriers, and social determinants of health [SDOH]) to facilitate vaccination uptake in clinical and community contexts.

Notice of Special Interest (NOSI): Addressing Health Disparities Among Immigrant Populations Through Effective Interventions

Deadline: June 06, 2026
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The purpose of the immigrant health initiative is to support research to design and implement effective interventions to enhance health advantages and reduce health disparities among U.S. immigrant populations (particularly agricultural workers, unaccompanied minors, first generation immigrants, and children of immigrant families) and address factors related to immigration experiences that affect health. For this Notice of Special Interest (NOSI), the term "1st generation" refers to people who were born outside of the U.S. and its territories and relocated to the U.S. The term "2nd generation" refers to the U.S. born children of 1st generation immigrants.

Standardizing Data and Metadata from Wearable Devices (R01 Clinical Trial Not Allowed)

Deadline: June 11, 2026
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Wearable technology shows promise in providing information that can be used to create biomarkers of various diagnostic groups that have relevance to mental illness. However, there are barriers related to multiple and sometimes proprietary data standards that make data aggregation difficult from existing devices. The purpose of this Notice of Funding Opportunity (NOFO) is to support the creation of standards for data as well as metadata and related coordination activities that will allow researchers to easily access data from personal tracking devices and integrate those data for subsequent data analysis. The recipients will be expected to partner with device manufacturers, the researcher community, and other interested parties such as ethics experts if the effort is going to be successful. It is expected that the recipient will create standards for personal tracking device data that serve the same purpose as the Digital Imaging and Communications in Medicine (DICOM) or Neuroimaging Informatics Technology Initiative (NIfTI) formats and standards do for medical image files. Those medical image file standards have allowed secondary data analysis and have resulted in many software packages and workflows for secondary data analysis.

Using Innovative Digital Healthcare Solutions to Improve Quality at the Point of Care (R21/R33 - Clinical Trial Optional)

Deadline: August 01, 2026
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This NOFO invites applications that propose research projects that test promising digital healthcare interventions used at the point of care and aimed at improving the quality of healthcare services delivery. This NOFO will use the Phased Innovation Award (R21/R33) mechanism to provide up to 2 years of R21 support for initial developmental activities, and up to 3 years of R33 support for expanded activities.

Notice of Special Interest (NOSI): Small Business Initiatives for Innovative tools and Technologies for Improving Outcomes for Maternal Health

Deadline: September 06, 2026
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This NOSI is intended to encourage interest in the small business community to develop various approaches, technologies, and tools to address the health issues of maternal morbidity and mortality by achieving a wide array of outcomes, such as 1) the identification, phenotyping, subtyping, and stratification of patients at a greater risk of MMM, 2) multi-level interventions to address racial disparities in MMM, and 3) clinical decision-making that considers social and cultural biases.

Notice of Special Interest (NOSI): Interventions to promote mental well-being in populations that experience health disparities through social, cultural, and environmental connectedness

Deadline: September 08, 2026
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The Office of Disease Prevention (ODP) and participating National Institutes of Health (NIH) Institutes, Centers, and Offices (ICOs) are soliciting intervention projects to promote mental well-being and/or prevent mental health problems by fostering social, cultural, or environmental connectedness in one or more populations that experience health disparities. Mental health or mental wellness may be the primary outcome of the intervention and/or an intermediate factor to improve other health outcomes.

Notice of Special Interest (NOSI): Implementation Science to Advance the United States HIV Prevention and Treatment Goals and the Global HIV Prevention and Treatment Targets

Deadline: September 08, 2026
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The National Institute of Mental Health (NIMH) is issuing this Notice to highlight interest in receiving implementation research grant applications designed in partnership with domestic and global service providers to advance HIV prevention and treatment goals (domestically) or targets (globally). These applications should target the unique needs in jurisdictions, both in cities and rural areas, that have been disproportionally affected by the HIV epidemic in the U.S. and globally. This NOSI is a reissue of NOT-MH-20-024.

Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)

Deadline: September 08, 2026
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Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) along with other participating Institutes encourages submission of applications proposing to conduct secondary data analysis and integration of existing datasets and database resources, with the ultimate aim to elucidate cancer risk and related outcomes (e.g., risk prediction or reduction, survival, or response to treatment, etc.). The goal of this initiative is to address key scientific questions relevant to cancer by supporting the analysis of existing clinical, environmental, surveillance, health services, vital statistics, behavioral, lifestyle, genomic, and molecular profiles data. Applicants are encouraged to leverage and perform innovative analyses of the existing data. Applications may include new research aims that are being addressed with existing data, new or advanced methods of analyses, or novel combinations and integration of datasets that allow the exploration of important scientific questions in cancer research.

Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)

Deadline: September 08, 2026
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Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for projects to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research.
The NCI, through this NOFO, encourages submission of projects devoted to demonstrating that mammalian models, including organoids, tumoroids and cell models, used for translational research are robust representations of human biology, are appropriate to test questions of clinical importance, and provide reliable information for patient benefit. These practical goals contrast with the goals of many mechanistic, NCI-supported R01 projects that use mammals, or develop and use mammalian cancer models, transplantation tumor models, or models derived from mammalian or human tissues or cells for hypothesis-testing, non-clinical research. Among many other possible endeavors, applicants in response to this NOFO could propose demonstrations of how to overcome translational deficiencies of mammalian oncology models, define new uses of mammalian models or their genetics for unexplored translational challenges, advance standard practices for use of translational models, test approaches to validate and credential models, or challenge current practices for how models are used translationally.

Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)

Deadline: September 08, 2026
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Notice of Special Interest (NOSI): Assessing Real-World Effectiveness and Implementation of Telehealth-Guided Provider-to-Provider Communication among Rural Communities

Deadline: October 10, 2026
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This Notice of Special Interest (NOSI) aims to support research that generates evidence on the real-world effectiveness of telehealth collaboration among healthcare providers for consultation, second opinions, and other purposes, referred to as provider-to-provider telehealth (PPT). PPT offers remote access to critical health expertise that might not exist locally in certain communities. For the purpose of this NOSI, PPT is defined broadly to include any health technology meant to connect healthcare providers to one another for the care of patients (e.g., video, chat or audio consults with a clinical specialist for patients under the care of a primary care clinician located in another healthcare facility).

Research supported by this NOSI is expected to:

Contribute to the advancement of health equity and access to care in rural communities through implementation research focused on telehealth-guided provider-to-provider communication;

Stimulate evidence-based interventional and observational research to investigate the real-world effectiveness of provider-to-provider telehealth in managing the health of rural populations while observing, gathering, and assessing information on implementation;

In settings where evidence of clinical effectiveness of PPT is robust, develop and test implementation strategies while observing and gathering information on the intervention’s impact on relevant outcomes.

This NOSI is intended to support the use of these telehealth interventions and tools aimed at the prevention, management and treatment of heart, lung, blood, and sleep (HLBS) conditions (NHLBI), and of cancer (NCI) in rural communities.

In addition to funding consideration by participating ICs, meritorious applications may be supported jointly by a participating IC and the National Institute of General Medical Sciences (NIGMS) through IDeA co-funding.

Notice of Special Interest (NOSI): Promoting Data Reuse for Health Research

Deadline: November 04, 2026
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This Notice of Special Interest (NOSI) solicits competitive revision applications that focus on data reuse and secondary data analysis in NIH-funded data repositories and knowledgebases to advance scientific inquiry and address health research questions.

Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)

Deadline: November 19, 2026
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This Notice of Funding Opportunity (NOFO) invites Research Project Grant (R01) applications that propose to study the ethical, legal and social implications (ELSI) of human genetic or genomic research. Applications may propose studies using either single or mixed methods. Approaches may include but are not limited to empirical qualitative and quantitative methods, and conceptual, legal, and normative analyses. Applied research designed to address ELSI issues in genetics and genomics will also be considered responsive. Direct engagement with communities and other interested groups is encouraged, but not required.

Notice of Special Interest: R13 Support for Conferences and Scientific Meetings to Support Consensus Building for Autoimmune Disease Research Related Common Data Elements

Deadline: December 14, 2026
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The purpose of this notice is to encourage the submission of “permission-to-submit” applications for R13 proposals seeking funding for the support of scientific conferences and workshops that will bring together subject matter experts in autoimmune disease research with the goal of developing and refining Common Data Elements (CDEs) for autoimmune disease research.

The use of CDEs supports the 2023 NIH Data Management and Sharing Policy by facilitating harmonization of data from different studies and interoperability.

Notice of Special Interest: R13 Support for Conferences and Scientific Meetings to Support Consensus Building for Autoimmune Disease Research Related Common Data Elements

Deadline: December 14, 2026
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The use of CDEs supports the 2023 NIH Data Management and Sharing Policy by facilitating harmonization of data from different studies and interoperability.

Notice of Special Interest: R13 Support for Conferences and Scientific Meetings to Support Consensus Building for Autoimmune Disease Research Related Common Data Elements

Deadline: December 14, 2026
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The use of CDEs supports the 2023 NIH Data Management and Sharing Policy by facilitating harmonization of data from different studies and interoperability.

Request for Information (RFI): Food is Medicine Research Opportunities

Deadline: January 01, 2027
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This Request for Information (RFI) invites input on research opportunities and best practices for Food is Medicine research programs. These programs are part of a whole-of-government approach to end hunger, improve nutrition and physical activity, and reduce diet-related diseases and disparities. Review of this entire RFI notice is encouraged to ensure a comprehensive response is prepared and to have a full understanding of how your response will be used.

Request for Information (RFI): Food is Medicine Research Opportunities

Deadline: January 01, 2027
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Request for Information: Prioritization of Drug, Vaccine, and Dietary Supplement Research Needs for Pregnant, Postpartum, and Lactating Persons

Deadline: January 01, 2027
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The NICHD invites all stakeholders to submit nominations for drug, vaccine, and dietary supplement research needs to be considered in the development of a Priority List of Drug, Vaccine, and Dietary Supplement Research Needs for Pregnant, Postpartum, and Lactating Persons. For the purpose of this RFI, the term drug is intended to include small molecule medications as well as biologic therapeutics (e.g., enzyme replacement therapy, monoclonal antibodies, gene therapy vectors, etc.) used for the treatment or prevention of a medical condition.

This RFI is intended to obtain information to help advance recommendations outlined in the 2018 Report of the Task Force for Research Specific to Pregnant and Lactating Women (PRGLAC) and 2020 PRGLAC Implementation Plan. The NICHD seeks information and actionable recommendations for potential priorities on research gaps and needs for drugs, vaccines, and dietary supplements used by pregnant, postpartum, or lactating persons. The NICHD is gathering nominations for drugs prescribed for conditions specific to or that co-occur during pregnancy and the postpartum period, including for lactation; dietary supplements that may be used in preparation for, during, or after pregnancy; and vaccines used by pregnant or lactating persons to prevent or treat disease. Additionally, the NICHD is seeking information on factors and processes it could consider in prioritizing these nominations.

Information provided that is not related to a specific drug, vaccine, dietary supplement, or potential factors to enable the conduct of clinical trials for a specific drug, vaccine, or dietary supplement (e.g., training, research collaborations, drug development tools) in consideration of their prioritization will be considered by the NICHD to be outside of the scope of this RFI.

All nominations must be submitted via a survey using the following link: https://www.surveymonkey.com/r/PRGLAC23.

Request for Information (RFI): Future Directions in Violence Against Women Research

Deadline: January 01, 2027
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This Request for Information (RFI) is intended to gather public input on priority scientific directions in violence against women (VAW) research. This includes cisgender, transgender, and gender-diverse persons who identify as a woman or girl, as well as other individuals assigned female at birth but who may not identify as a woman or girl. Specifically, the National Institute of Nursing Research (NINR), the Office of Research on Women's Health (ORWH), the National Institute of Child Health and Human Development (NICHD), the National Institute on Minority Health and Health Disparities (NIMHD), the Office of Behavioral and Social Sciences Research (OBSSR), the Office of Disease Prevention (ODP), and the Sexual & Gender Minority Research Office (SGMRO) are soliciting comments from the public on scientific gaps and research opportunities to address longstanding and emergent factors that perpetuate VAW. This request solicits input on a broad range of topics to inform research directions to better understand and identify opportunities to address underlying causes that influence women’s exposure to violence and to identify approaches to address the health impacts and sequelae of VAW.

In this request, VAW is considered broadly to include but not be limited to: domestic or intimate partner violence (IPV), sexual assault and rape, dating violence and abuse, peer violence, physical and mental abuse, sexual coercion, stalking, homicide, and elder mistreatment.

Notice Announcing Availability of Data Harmonization Tools for Social Determinants of Health (SDOH) via the PhenX Toolkit

Deadline: January 01, 2027
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The purpose of this Notice is to announce a major data-harmonization effort at the National Institute on Minority Health and Health Disparities (NIMHD) and to encourage the minority health and health disparities research community to use new data collection tools emerging from this effort.

The NIMHD is dedicated to advancing science by improving the yield and impact of its research portfolio. One way to accomplish this is to provide investigators with a common set of tools and resources that allow their work to span the diverse areas of the minority health and health disparities. Social determinants of health—the conditions in which people are born, grow, live, work and age—are known to drive health disparities. Recognizing this, the NIMHD, in collaboration with the National Human Genome Research Institute and the broader scientific community, has identified a series of Core and Specialty measures that will promote the collection of comparable data on social determinants of health (SDOH) across studies. The SDOH are categorized into categories of individual and structural factors that have impact on human health. The list of constructs and measures is not exhaustive and NIMHD will continue to work towards greater harmonization of measures through vetted common data elements in the science of minority health and health disparities.

The NIMHD and its partners in the scientific community strongly encourages investigators to incorporate the measures from the Core and Specialty collections available in the Social Determinants of Health Collections of the PhenX Toolkit (www.phenxtoolkit.org) whenever possible.

Core collection: The measures in this collection are deemed relevant and essential to all areas of minority health and health disparities. Funded investigators are strongly encouraged to incorporate, at a minimum, the Core-Tier 1 measures in all primary data collection.

Specialty collections: The measures in these collections are organized at the individual and structural levels for more nuanced investigations of how SDOH influence health. The Individual SDOH Specialty collection includes measurement protocols for use in research where information is being collected from and about people answering for themselves or their family. The Structural SDOH Specialty collection includes measurement protocols at the structural or community level. Funded investigators conducting research in the specified areas of science are strongly encouraged to incorporate the Specialty measures related to the specific concepts covered and are discouraged from using alternative measures in lieu of the Specialty measures to collect similar data.

Through the use of these SDOH measures and common data elements, minority health and health disparity researchers will be able to share, compare, and integrate data across studies. By advocating the use of these common measures, the NIMHD and its partners in the scientific community aim to further enhance the science of minority health and health disparities while advancing a culture of scientific collaboration.

Unveiling Health and Healthcare Disparities in Non-Communicable and Chronic Diseases in Latin America: Setting the Stage for Better Health Outcomes Across the Hemisphere (R01 - Clinical Trials Not Allowed)

Deadline: January 07, 2027
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This Notice of Funding Opportunity (NOFO) will support innovative, collaborative, and interdisciplinary research focused on clinical epidemiology, evaluation of public and/or health care policies, and validation of measurements that address health and healthcare disparities related to non-communicable and chronic diseases (NCDs) with the highest disease burden and mortality in Latin America and among U.S. Hispanics/Latinos.

Notice of Special Interest (NOSI): Advancing Diet and Physical Activity Biomarkers for Assessing Lifestyle Interventions in Cancer Prevention and Cancer Interception Research

Deadline: January 08, 2027
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This Notice of Special Interest (NOSI) is to support applications improving diet and/or physical activity assessment biomarker development for evaluating lifestyle-based cancer prevention and interception approaches across diverse settings. Multiple principal investigator structured applications with the appropriate expertise are encouraged to apply. Preclinical and pilot human studies assessing baseline and recovery biomarkers for dietary intake, nutritional status, and/or physical activity intervention(s) as complementary exposures are important for early cancer prevention and its interception in high-risk individuals or groups.

Understanding the Impact of Healthcare System and Clinician Factors on Disparities in Maternal Morbidity and Mortality (R01 - Clinical Trial Optional)

Deadline: January 08, 2027
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The purpose of this Notice of Funding Opportunity (NOFO) is to support multidisciplinary and innovative intervention research to understand and address maternal morbidity and mortality in the United States, particularly but not exclusively among racial and ethnic minority, socioeconomically disadvantaged, and underserved rural populations, with a focus on understudied healthcare factors.

This is a new funding opportunity to advance the goals of the NIH Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE) Initiative. IMPROVE aims to understand the biological, behavioral, environmental, sociocultural, clinical, and structural factors that affect pregnancy-related and pregnancy-associated severe morbidity and mortality and build an evidence base for improved care and outcomes. The IMPROVE initiative supports research to reduce preventable causes of maternal deaths and improve health for women before, during, and after delivery. It includes a special emphasis on health disparities and populations that are disproportionately affected, such as racial and ethnic minority persons, very young women and women of advanced maternal age, and people with disabilities.

Notice of Special Interest (NOSI): Data Informed, Place-Based Community-Engaged Research to Advance Health Equity

Deadline: January 08, 2027
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The purpose of this NOSI is to stimulate community-engaged research that leverages geospatial data to probe the influence of geographic factors on disease development and health outcomes. Our goal is to use place-based research to help advance health equity in different communities. Applicants must select the IC and associated NOFO to use for submission of an application in response to the NOSI. The selection must align with the IC requirements listed in order to be considered responsive to that NOFO. Non-responsive applications will be withdrawn from consideration for this initiative. In addition, applicants using NIH Parent announcements (listed below) will be assigned to those ICs on this NOSI that have indicated those NOFOs are acceptable and based on usual application-IC assignment practices.

Interventions to expand cancer screening and preventive services to ADVANCE health in populations that experience health disparities (R01, Clinical Trial Required)

Deadline: January 08, 2027
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The Office of Disease Prevention (ODP) and participating National Institutes of Health (NIH) Institutes, Centers, and Offices (ICs) are issuing this R01 to solicit applications to address barriers and facilitators that impede use or uptake of cancer screening and preventive services in populations that experience health disparities. Interventions should include screening, preventive services, or other healthcare processes, including timely follow-up of abnormal findings, and referral to accessible care. Projects are encouraged to leverage collaborations with community partners and service providers. Interventions should address barriers and facilitators at two or more of the following levels: patient, clinician, healthcare setting, and neighborhood/community. Specific research interests of participating NIH ICs are detailed within.

Projects are encouraged to leverage collaborations with community partners and service providers to promote or enhance existing interventions and/or adapt new combinations of evidence-based strategies. Interventions should address barriers and facilitators at two or more of the following levels: patient, clinician, healthcare setting, and neighborhood/community.

Notice of Special Interest (NOSI): Data Informed, Place-Based Community-Engaged Research to Advance Health Equity

Deadline: January 08, 2027
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Personal Health Informatics for Delivering Actionable Insights to Individuals (R01 Clinical Trial Optional)

Deadline: January 08, 2027
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The purpose of this Notice of Funding Opportunity (NOFO) is to advance the development of novel informatics and data science approaches that can help individuals understand and improve their health through actionable insights. The NLM and participating institutes listed in this NOFO seek applications that further the science of personal health informatics by providing meaningful and actionable insights to individuals through innovative personal health data collection, integration, analysis, and personalized risk assessments and interpretation. Applications seeking to advance the understanding of how informatics tools, systems, and platforms can best present the results, interpretation, and limitations of personalized assessments for the benefit of individuals are encouraged. Applications should include end user engaged approaches and real-world evaluation to inform the design of generalizable, reusable, and scalable personal health informatics tools, systems, and platforms for the benefit of individuals in understanding and improving their health.

Improving Care and Outcomes for Cancer Survivors from Sexual and Gender Minority (SGM) Populations (R01 Clinical Trial Optional)

Deadline: January 08, 2027
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Through this notice of funding opportunity (NOFO), the National Cancer Institute (NCI) intends to support the rigorous assessment of barriers to quality cancer treatment and follow-up care for sexual and gender minority (SGM) cancer survivors. This funding opportunity is intended to address a critical need for improved care delivery and outcomes for SGM cancer survivors. The goal is to address the disease burden in an underserved and understudied population that is at higher risk of poorer health outcomes. The NCI solicits proposals for observational and/or interventional studies of SGM survivors designed to understand barriers and/or improve care and outcomes for SGM people with cancer, using interoperable sexual orientation and gender identity (SOGI) data collection in cancer care settings, where appropriate.

Notice of Special Interest (NOSI): Data Informed, Place-Based Community-Engaged Research to Advance Health Equity

Deadline: January 08, 2027
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Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)

Deadline: February 05, 2027
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The purpose of this initiative is to advance the science of minority health and health disparities by supporting research on family health and well-being and resilience. The NIMHD Research Framework recognizes family health, family well-being, and family resilience as important areas of research to decrease disparities and improve outcomes.

Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)

Deadline: May 08, 2027
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The purpose of this initiative is to advance the science of minority health and health disparities by supporting research on family health and well-being and resilience. The NIMHD Research Framework recognizes family health, family well-being, and family resilience as critically important areas of research to decrease disparities and promote equity.

Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities (R01, Clinical Trial Required)

Deadline: May 08, 2027
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The Office of Disease Prevention (ODP) and participating National Institutes of Health (NIH) Institutes, Centers, and Offices (ICOs) are issuing this NOFO seeking applications to test innovative approaches to implementing SBIRT/P for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities. SBIRT/P, (a term used for purposes of this funding announcement), involves screening individuals for risk of ATOD use and misuse, briefly intervening with a conversation about harmful substance use, and referring individuals for treatment or preventive services, as needed.

Proposed research should include prospective tests of SBIRT/P and should leverage collaborations with healthcare and community partners Specific research interests of participating NIH ICOs are detailed within.

Interventions on Health and Healthcare Disparities on Non-Communicable and Chronic Diseases in Latin America: Improving Health Outcomes Across the Hemisphere (R01 - Clinical Trial Required)

Deadline: May 08, 2027
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This Notice of Funding Opportunity (NOFO) is being reissued in accordance with the simplified review criteria in effect for application due dates after January 25, 2025.

The purpose of this Notice of Funding Opportunity (NOFO) is to support innovative and interdisciplinary team research focused on clinical, health services, and/or community-based interventions that address health and healthcare disparities related to non-communicable and chronic diseases (NCDs) with the highest disease burden and mortality in Latin America and among U.S. Hispanics/Latinos.

Notice of Special Interest (NOSI): Neuromodulatory Control of Circuits Underlying Mental Health Relevant Behaviors

Deadline: May 10, 2027
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This Notice of Special Interest (NOSI) solicits applications seeking to understand how neuromodulatory signals dynamically control and coordinate neural circuit responses in real-time during complex mental health relevant behaviors including cognitive, social, and affective functions. These studies are expected to utilize recent tools that enable precise assessment of spatiotemporal dynamics of extracellular release or receptor activation of neuromodulators with simultaneous causal interrogation of neural activity and behavioral responses.

Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional)

Deadline: June 02, 2027
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The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate the development of effective precision probiotic interventions using a milestone-driven, biphasic award mechanism. It aims to identify, understand, and develop strategies to address barriers in precision probiotic interventions to account for the heterogeneity in humans that often causes inconsistent probiotic therapeutic responses. Specifically, this NOFO solicits applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders, which may then help enhance probiotic clinical outcomes.

Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional)

Deadline: June 05, 2027
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Health Disparities Research Project Grants (RPG), including those to be supported by this initiative on interventions to reduce sleep health disparities, support innovative projects to enhance our understanding of biological mechanisms, social, behavioral, and health services that can directly and demonstrably contribute to the improvement in minority health and the elimination of health disparities.

Notice of Special Interest (NOSI): Improving Adherence to Treatment and Prevention Regimens and Maintenance of Health Behaviors to Promote Health

Deadline: July 24, 2027
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This Notice of Special Interest (NOSI) is being re-issued by the NIH Adherence Network through the Office of Behavioral and Social Sciences Research (OBSSR), with participation from multiple NIH Institutes, Centers, and Offices. This NOSI calls for research grant applications that address adherence to recommended treatment and prevention regimens or maintenance of behaviors to promote positive health outcomes (collectively referred to as health behaviors). Applications may address health behavior initiation, execution, and/or persistence through mechanistic studies, efficacy trials, or implementation research. Descriptive studies and intervention research may address relevant determinants at one or more levels of ecologic influence, including the individual, caregiver/family, provider, healthcare system, and community levels. Approaches designed to reduce health disparities and improve equitable health outcomes are strongly encouraged.

Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional)

Deadline: September 08, 2027
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The purpose of this initiative is to support non-pharmacological interventions to promote sleep health, reduce sleep health disparities, and examine sleep as a modifiable factor to reduce disparities for other health outcomes among populations that experience health disparities.

Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional)

Deadline: September 08, 2027
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Notice of Special Interest (NOSI): Analysis of Existing Linked Datasets to Understand the Relationship between Housing Program Participation and Risk for Chronic Diseases and Other Conditions (R01-Clinical Trial Not Allowed)

Deadline: September 08, 2027
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This Notice of Special Interest (NOSI) expresses the interest of the participating Institutes and Offices in the evaluation of the effects of housing program participation on risk for chronic diseases and conditions within the missions of the participating Institutes and Offices. Housing programs or policies of interest may be supported by federal, state, or local-level agencies or organizations. Applications in response to this NOSI must propose to evaluate existing datasets with housing program participation data that can be administratively linked to health outcome data. Projects that propose to evaluate longitudinal health outcomes are particularly encouraged.

Notice of Special Interest (NOSI): Advancing Research to Address the Heterogeneity of Obesity Risk, Related Health Outcomes, and Response to Treatment

Deadline: September 08, 2027
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This Notice of Special Interest (NOSI) aims to increase research to understand the heterogeneity of obesity phenotypes and the underlying mechanisms that protect against or increase risk for obesity and obesity-associated conditions. The objective of this NOSI is to support research applications that address knowledge and portfolio gaps regarding the role of obesity in disease development. Understanding the heterogeneity of obesity is necessary for precision and targeted implementation of obesity prevention and treatment interventions. Responsive proposals would include those aiming to investigate biological or nonbiological mechanisms through which adiposity differentially affects health. Other responsive applications might include those evaluating heterogeneity in response to obesity prevention and treatment, based on biological (e.g., genetic), behavioral, and/or racial/ethnic factors.

Notice of Special Interest (NOSI): Determining the Tri-directional Relationship Among Oral Health, Nutrition, and Comprehensive Health

Deadline: September 08, 2027
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The National Institute of Dental and Craniofacial Research (NIDCR) is issuing this Notice of Special Interest (NOSI) to encourage research on the interplay of nutrition/food insecurity, oral diseases, and comprehensive health across the life span. The purpose of this NOSI is to support research to better understand the mechanisms of the tri-directional relationship among nutrition, systemic health, and oral, dental, and craniofacial (DOC) health and the development of nutritional interventions in the dental setting.

Diet-related metabolic and cardiovascular diseases are among the leading causes of death and disability in the U.S. One in 10 Americans have type 2 diabetes. More than 4 in 10 Americans have hypertension, which is linked to heart disease and stroke, the leading causes of death for Americans. Diseases related to poor nutrition and food insecurity are largely preventable conditions.

Because the mouth is the entryway for foods and fluids, any changes in the oral cavity, including tooth loss and caries, can skew food choices toward carbohydrates and foods with low nutritional value, thus further negatively affecting oral and systemic health. Diabetes exacerbates periodontal disease and delays wound healing. Mid-pregnancy maternal vitamin D deficiencies have been associated with enamel hypoplasia in children, which increases susceptibility to dental caries. Sweetened beverage intake is strongly associated with tooth decay and tooth loss in US children. Parents and caregivers play a role in preventing and controlling childhood dental caries through oral hygiene practices and healthy food choices. Individuals from rural, lower socioeconomic, and minority populations have a higher incidence of oral diseases, which ultimately impacts food intake and nutrition. However, the interplay among oral health, nutrition, and comprehensive health is still poorly understood. Pillar 5 of the White House National Strategy on Hunger, Nutrition, and Health recognizes the public health need to advance research regarding the prevention and treatment of diet-related diseases including the tri-directional relationship among oral health, nutrition, and comprehensive health.

Mood and Psychosis Symptoms during the Menopause Transition (R01 Clinical Trial Optional)

Deadline: October 05, 2027
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The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications that will advance mechanistic and translational research on the onset and worsening of mood and psychotic disorders during the menopausal transition (or perimenopause). In particular, NIMH seeks research that will advance understanding of the underlying neurobiological and behavioral mechanisms of mood disruption, emotion dysregulation, and psychosis during the menopausal transition and that will identify novel targets for future mental health interventions or prevention efforts

Modular R01s in Cancer Control and Population Sciences (R01 Clinical Trial Optional)

Deadline: October 05, 2027
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This notice of funding opportunity (NOFO) encourages applications for research in cancer control and population sciences. The overarching goal is to provide support to promote research efforts on novel scientific ideas that have the potential to substantially advance cancer research in statistical and analytic methods, epidemiology, cancer survivorship, cancer-related behaviors and behavioral interventions, health care delivery, digital health and data science, and implementation science.

Laboratories to Optimize Digital Health (R01 Clinical Trial Required)

Deadline: October 05, 2027
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NIMH seeks applications for innovative research projects to test strategies to increase the reach, efficiency, effectiveness, and quality of digital mental health interventions which may impact mental health outcomes, including suicide behaviors and serious mental illness. This Notice of Funding Opportunity (NOFO) is intended to support the development of digital health test beds that leverage well-established digital health platforms and infrastructure to rapidly refine and optimize existing evidence-based digital health interventions and to conduct clinical research testing digital mental health interventions that are statistically powered to provide a definitive answer regarding the intervention's effectiveness particularly in populations who experience health disparities and vulnerable populations.

Molecular Imaging of Inflammation in Cancer (R01 Clinical Trial Not Allowed)

Deadline: October 05, 2027
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Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites research grant applications (R01) for the development and application of current and emerging molecular imaging methods to gain fundamental insights into cancer inflammation in vivo.

The motivation for this initiative is the recognition that much of the current imaging research on inflammation in cancer relies heavily on in vitro and ex vivo methods. These approaches have limited potential to provide significant insights into the dynamic interactions between cancer and inflammation. Utilizing molecular imaging probes in pre-clinical and clinical investigations allows for precise temporal resolution at molecular and cellular levels. This information is valuable for identifying and characterizing in vivo inflammatory cellular physiology in cancer and for detecting molecular changes in response to treatment.

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

Deadline: October 05, 2027
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The purpose of this Notice of Funding Opportunity (NOFO) is to support studies that will identify, develop, and/or test strategies for overcoming barriers to the adoption, adaptation, integration, sustainability, scale-up, and spread of evidence-based interventions, practices, programs, tools, treatments, guidelines, and policies (hereafter referred to as evidence-based interventions). Studies that promote the dissemination and implementation of evidence-based interventions among relevant communities are encouraged. Conversely, there is a benefit in understanding circumstances that create a need to stop or reduce (de-implement) the use of practices that are ineffective, unproven, low-value, or harmful. In addition, studies to advance dissemination and implementation research methods and measures are encouraged. Applications that focus on re-implementation of evidence-based health services that may be disrupted amidst disasters remain relevant.

All applications must be within the scope of the mission of one of the Institutes/Centers listed above.

Advancing Healthcare for Older Adults from Populations that Experience Health Disparities (R01 - Clinical Trial Optional)

Deadline: October 05, 2027
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The purpose of this initiative is to advance the science and implementation of innovative multi-level health care research for older adults from populations that experience health disparities. The initiative will support research designed to (1) gain a better understanding of appropriate screening, diagnostic, and clinical care guidelines in a primary care setting, (2) explore shared decision-making that is needed to enhance care planning and patient agency between clinicians and care teams with the older adult and their caregiver(s), and (3) identify effective strategies for care coordination.

Notice of Special Interest: Women’s Health Research

Deadline: November 05, 2027
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In alignment with the White House Initiative on Women’s Health Research, the National Institutes of Health (NIH) is issuing this Notice of Special Interest to highlight interest in receiving research applications focused on diseases and health conditions that predominantly affect women (e.g., autoimmune diseases; depressive disorders, Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD), gender-based-violence), present and progress differently in women (e.g., cardiovascular disease; HIV; reproductive aging and its implications), or are female-specific (e.g., uterine fibroids; endometriosis; menopause).

For consideration under this NOSI, applications must have a central focus on the health of women, as demonstrated through specific aims that EITHER explicitly address a particular condition in women OR focus on one of the high priority topics below. In either approach, intersectional and/or multidimensional approaches that consider the health of women in context (e.g., projects accounting for social and structural variables—including race, ethnicity, socioeconomic status , and State and Federal policies— that affect women’s health) are strongly encouraged. For consideration under this NOSI, projects are not required to exclusively focus on women. However, studies that include more than one sex or gender should be designed and powered to make generalizable conclusions about women and enable sex or gender difference comparison.

Notice of Special Interest (NOSI): Developing and Testing Multi-level Physical Activity Interventions to Improve Health and Well-Being

Deadline: November 14, 2027
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The Office of Disease Prevention and participating Institutes, Centers and Offices (ICOs) are issuing this Notice to highlight our interest in highly innovative multi-level interventions to increase and maintain health-enhancing physical activity in a wide range of population groups, including populations that experience health disparities, children, older adults, and persons at risk for mental/behavioral health conditions, and any subpopulations that can be characterized by the intersection of two or more of these descriptors. Relevant physical activity intervention research includes translational research for pilot, exploratory, or developmental work in preparation for full-scale, fully powered efficacy studies, as well as studies seeking to adopt existing evidence-based interventions in a new context (e.g., population, setting, etc.). Research studies should be based on well-established theory, existing data, and/or evidence-based interventions. Furthermore, studies may focus on establishing efficacy, effectiveness, or dissemination and implementation of multi-level interventions.

Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional)

Deadline: November 15, 2027
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The purpose of this Notice of Funding Opportunity (NOFO) is to leverage NICHD clinical research network infrastructure relevant to infants, children, women, including those who are pregnant and lactating, and persons with disabilities to conduct innovative, multisite, investigator-initiated clinical trials and observational studies. This NOFO will utilize a bi-phasic (UG3/UH3), milestone-driven mechanism consisting of a start-up phase (UG3) and a full enrollment and clinical study implementation phase (UH3). Applications submitted in response to this NOFO must address specific aims and milestones for both the UG3 and UH3 phases. A UG3 project (phase I) that meets its milestones will be administratively considered by NICHD and prioritized for transition to the UH3 award (phase II). This NOFO provides an opportunity to leverage NICHD clinical research network infrastructure as a platform for investigator-initiated innovative hypotheses by any investigator in the extramural community. Applications must be submitted as investigator-initiated, multi-Project Director/Principal Investigator (PD/PI) grant applications in conjunction with the respective NICHD-supported Network Data Coordinating Center (DCC), or equivalent as determined by the NICHD.

Notice of Special Interest (NOSI): Understanding Exposure and Health Effects of Micro and/or Nanoplastics

Deadline: November 17, 2027
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The purpose of this Notice of Special Interest (NOSI) is to inform potential applicants that the National Institute of Environmental Health Sciences (NIEHS), has special interest in applications that investigate exposure to, and health effects of, microplastics (MPs) and nanoplastics (NPs).

Notice of Special Interest (NOSI): Effectiveness of Mobile Health Clinics to Advance Health Equity

Deadline: November 17, 2027
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The term “Mobile Health Clinic (MHC)” refers to a community-based model of healthcare delivery in which health services are delivered from a motorized vehicle within communities. Sometimes referred to as “Mobile Health Units”, “Mobile Clinics”, or described as “Healthcare on Wheels,” the MHC is usually a bus, truck or van that transports medical personnel and contains the clinical resources (e.g., examination table, laboratory supplies for point of care testing, and medical equipment) that are necessary to provide health care (e.g. primary care, behavioral health, dental, vision, specialized care or other health services).

The term “populations that experience health disparities” refers to the NIH-designated United States (US) health disparity populations which include Blacks/African Americans, Hispanics/Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, Middle Eastern/North Africans, socioeconomically disadvantaged populations, underserved rural populations, sexual and gender minority groups, and people with disabilities (https://www.nimhd.nih.gov/about/overview/).

The term “multi-level” refers to determinants at two or more socioecological levels of interest (e.g., individual, family, clinician, health care system, community) that are relevant for understanding and addressing minority health and health disparities. This concept is further described under the NIMHD Research Framework (https://www.nimhd.nih.gov/about/overview/research-framework/).

The Role of Work in Health Disparities in the U.S. (R01 Clinical Trials Optional)

Deadline: January 08, 2028
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The purpose of this Notice of Funding Opportunity (NOFO) is to support innovative population-based research that can contribute to identifying and characterizing pathways and mechanisms through which work or occupation influences health outcomes and health status among populations with health and/or health care disparities.

Advancing Research at the intersection of Biology and Artificial Intelligence (AI)/Machine Learning (ML)

Deadline: January 08, 2028
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Encourages proposals that advance biological research through use of Artificial Intelligence/Machine Learning (AI/ML) or through development of AI/ML methods using biological data and systems in areas supported by the four Divisions of the BIO Directorate.

Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R01 Clinical Trial Not Allowed)

Deadline: January 08, 2028
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The purpose of this notice of funding opportunity (NOFO) is to encourage applications seeking to develop the next generation of brain stimulation devices for treating mental health disorders. Applications are encouraged that will either 1) develop novel brain stimulation devices or 2) significantly enhance, by means of hardware/software improvements, the effectiveness of brain stimulation devices that are currently U.S. Food and Drug Administration (FDA)-approved or cleared. Applications to this NOFO are not expected to be hypothesis-driven, but should propose design-directed, developmental, or discovery-driven technology research using integrative approaches. Although the application should focus on the engineering development and bench top testing of the tool, animal and limited, non-clinical trial human testing necessary to demonstrate initial proof of concept is allowable. This NOFO uses the R01 grant mechanism, encouraging longer term projects, whereas the companion NOFO, PAR-25-286 seeks grant applications encouraging shorter duration, high-risk studies.

Mood and Psychosis Symptoms during the Menopause Transition (R01 Clinical Trial Optional)

Deadline: January 08, 2028
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This NOFO uses the R01 grant mechanism, while the companion NOFO PAR-25-282 uses the R21 mechanism. Investigators proposing high risk/high reward projects, projects that lack preliminary data, or studies that utilize existing data may wish to apply using the R21 mechanism, while applicants with preliminary data who seek longer-term funding may wish to apply using the R01 mechanism.

Research With Activities Related to Diversity (ReWARD) (R01 Clinical Trial Optional)

Deadline: January 08, 2028
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The NIH Research With Activities Related to Diversity (ReWARD) Program's overarching goal is to enhance the breadth and geographical location of research and research-related activities supported by NIH. The ReWARD program provides support for the health-related research of scientists who are making a significant contribution to Diversity, Equity, Inclusion, and Accessibility (DEIA) and who have no current NIH research project grant funding. The ReWARD program provides funding for both the scientific research and the DEIA activities of investigators. The grant will support scientific research in areas related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) and DEIA activities focused on enhancing diversity in the biomedical research enterprise within the United States and territories.

Laboratories to Optimize Digital Health (R01 Clinical Trial Required)

Deadline: January 08, 2028
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Integrating Mental Health Care into Health Care Systems and Non-Health Settings in Low- and Middle-Income Countries (R01 Clinical Trial Optional)

Deadline: January 08, 2028
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This notice of funding opportunity (NOFO) seeks implementation research projects focused on the integrating mental health services with chronic health care (for both communicable and non-communicable conditions) across various healthcare and non-healthcare settings (such as schools, places of worship, and community centers) in low and middle-income countries (LMICs). The objective is to develop, refine, and evaluate innovative strategies to facilitate the integration of mental health care with other services. This NOFO aims to support research geared towards implementing, scaling up, and ensuring the financial sustainability of integrated mental health care models, with the overarching goal of enhancing the availability, accessibility, utilization, and quality of mental health care services in both healthcare and non-healthcare settings. In addition, this NOFO seeks to strengthen sustainable mental health research capacity in LMICs.

Molecular Imaging of Inflammation in Cancer (R01 Clinical Trial Not Allowed)

Deadline: January 08, 2028
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This NOFO encourages applications focused on developing integrated imaging approaches to investigate the role of inflammation in cancer through strong cross-discipline collaboration between cancer basic science researchers and imaging scientists. These collaborations are expected to advance the science and understanding of cancer inflammation interactions.

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

Deadline: January 08, 2028
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The purpose of this Notice of Funding Opportunity (NOFO) is to support studies that will identify, develop, and/or test strategies for overcoming barriers to the adoption, adaptation, integration, sustainability, scale-up, and spread of evidence-based interventions, practices, programs, tools, treatments, guidelines, and policies (hereafter referred to as evidence-based interventions). Studies that promote equitable dissemination and implementation of evidence-based interventions among underrepresented communities are encouraged. Conversely, there is a benefit in understanding circumstances that create a need to stop or reduce (de-implement) the use of practices that are ineffective, unproven, low-value, or harmful. In addition, studies to advance dissemination and implementation research methods and measures are encouraged. Applications that focus on re-implementation of evidence-based health services that may be disrupted amidst disasters (e.g., pandemics, climate change) remain relevant.

All applications must be within the scope of the mission of one of the Institutes/Centers listed above.

This Notice of Funding Opportunity (NOFO) requires a Plan for Enhancing Diverse Perspectives (PEDP).

Advancing Healthcare for Older Adults from Populations that Experience Health Disparities (R01- Clinical Trial Optional)

Deadline: January 08, 2028
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Amplifying STEM Education Investments in and with Rural and Remote Areas and Communities

Deadline: January 08, 2028
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The Directorate for STEM Education (EDU) seeks new proposal submissions to continue its support for science, technology, engineering, mathematics, and computer science education innovations, research, capacity, and workforce development in and with rural and remote communities. Through this Dear Colleague Letter (DCL), EDU acknowledges the multidimensionality of rural America and welcomes proposals that meet the specific needs and that leverage the wide-ranging assets and opportunities of rural and remote communities, such as the Delta Region, Appalachia, and Tribal and EPSCoR (Established Program to Stimulate Competitive Research) jurisdictions.