Recent News
10 Purdue faculty chosen as fellows of the American Association for the Advancement of Science
March 27, 2025
Ramaswamy Subramanian, the Gerald and Edna Mann Director of the Bindley Bioscience Center, professor of biological sciences (College of Science) and professor in the Weldon School of Biomedical Engineering (College of Engineering), is being honored for seminal contributions to structural biology, enhancing atomic-level understanding of diverse biological processes, and for leading the development of scientific infrastructure in India and the U.S. Subramanian is an expert in structural biology and biophysics with an interest in understanding the relationship between atomic resolution structures and molecular function, with a focus on enzymes and membrane transporters.
10 Purdue faculty chosen as fellows of the American Association for the Advancement of Science
The Aryal Lab (Uma, Rodrigo, Punya, Aryaman, and Malyka) attended the 140th Indiana Academy of Science conference in Indianapolis on March 22, 2025, where they presented their latest proteomics and lipidomics research through talks and poster presentations.
March 25, 2025
The Aryal Lab (Uma, Rodrigo, Punya, Aryaman, and Malyka) attended the 140th Indiana Academy of Science conference in Indianapolis on March 22, 2025, where they presented their latest proteomics and lipidomics research through talks and poster presentations. Notably, Aryaman secured second place in the microbiology poster competition and Rodrigo won first place in the oral competition across all categories. Congratulations to both Aryaman and Rodrigo. Well done!
One Health: Control of protein folding strikes at the root of disease
February 13, 2025
The shared culprit in a slew of diseases — cancers, neurodegenerative diseases, diabetes — is molecules our cells have made incorrectly. Think of them as proteins gone wrong. Whether the cause is genetic or environmental, these proteins are improperly folded, fail to do their job and can accumulate in the body with devastating results. By looking for missteps in the intricate process of folding proteins, a project at Purdue University is paving the way for a new generation of therapeutics that strike at the root of these diseases.
One Health: Control of protein folding strikes at the root of disease
Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry
February 13, 2025
The Aryal lab, in collaboration with Dr. Schaser (Department of Speech, Language, and Hearing Sciences) and Dr. Ferreira (Bindley Bioscience Center) has published a study titled "Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry" in the Journal of Proteome Research. This study provides a comprehensive analysis of lipid alterations in the aging mouse brain and their potential links to neurodegenerative diseases. By employing multiple mass spectrometry-based lipidomic approaches, including Desorption Electrospray Ionization (DESI), a technique developed at Purdue, this research reveals age-dependent changes in lipid composition and their spatial distribution across different brain regions. The findings offer new insights into how lipid dysregulation may contribute to age-related neurological disorders.
Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry
Proteomic Analysis of Unicellular Cyanobacterium Crocosphaera subtropica ATCC 51142 under Extended Light or Dark Growth
February 6, 2025
The Aryal lab, in collaboration with the Kihara and Sherman labs at Purdue University, has published a study titled "Proteomic Analysis of Unicellular Cyanobacterium Crocosphaera subtropica ATCC 51142 under Extended Light or Dark Growth" in the Journal of Proteome Research. This research explores how cyanobacteria, key players in global carbon and nitrogen cycles, adapt their metabolism to prolonged light or dark conditions. By analyzing the cellular proteome of Crocosphaera subtropica 51142 beyond typical diurnal cycles, the study provides insights into how these photosynthetic bacteria integrate circadian and environmental cues to regulate essential processes like nitrogen fixation and photosynthesis.
Proteomic Analysis of Unicellular Cyanobacterium Crocosphaera subtropica ATCC 51142 under Extended Light or Dark Growth
A proteomic hunt for phosphosites in the aging brain
January 24, 2025
Proteins are cellular workhorses, executing important tasks based on their specific functions. However, misfolded, mutated, inactive or overactive proteins are often the culprits behind disorders, including neurodegenerative diseases. Researchers need a greater understanding of how aging drives protein dysfunction to develop strategies to slow or even reverse these diseases.
Unlocking the Mysteries of the Brain
November 22, 2024
Greater understanding of protein aggregation relative to aging is one small step toward slowing or even reversing neurogenerative diseases. Despite more than six decades of research in the field of neuroscience, many functions of the brain — the most complex organ in the human body — remain a mystery. Recent research conducted in the Purdue University College of Veterinary Medicine and the Bindley Bioscience Center revealed that scientists are one step closer to understanding the process that activates and deactivates specific proteins within our cells. This breakthrough could one day lead to enhanced treatments that may slow down or perhaps reverse the advance of neurogenerative diseases such as Alzheimer’s, Parkinson’s and multiple sclerosis.
Punyatoya Panda from Dr. Aryal's lab receives Kroenke Poster award
October 3, 2024
Punyatoya Panda was recently the recipient of the Kroenke Poster Award for "Outstanding Achievement in Scientific Poster Presentation and Translational Impact" from the Indiana CTSI Annual Meeting, 2024 that was held at IU, Indianapolis on 20th September.
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Unpacking molecular mystery of aging
October 3, 2024
Dr. Uma K. Aryal, a Research Associate Professor in the Department of Comparative Pathobiology at Purdue University’s College of Veterinary Medicine and Director of the Purdue Proteomics Facility at the Bindley Bioscience Center, and his team have recently published a groundbreaking study exploring the molecular signatures of aging. By analyzing the brains of mice from three different age groups, they performed a comprehensive proteomic analysis, mapping thousands of phosphorylation sites and examining how these modifications change with age. Leveraging advanced mass spectrometry technology at the Purdue Proteomics Facility and a novel multi-protease digestion approach, the team identified hundreds of phosphorylated proteins significantly affected by aging, including several known to be involved in Alzheimer's and Parkinson's diseases. This study provides valuable insights into age-related changes in the brain proteome, offering numerous potential protein targets for further research into how aging and neurodegenerative diseases like AD or PD impact brain function and contribute to disease progression.
Demystifying the Aging Process – Study Sheds New Light on Age-related Diseases
August 12, 2024
Identification of nuclear protein’s critical role in cell degradation could lead to prevention or even reversal of age-related diseases
Demystifying the Aging Process – Study Sheds New Light on Age-related Diseases