Training Group:

Molecular Signaling and Cancer Biology

Mentor / Lab:

Philip Low

Specific Research Area / Project:

Cancer is the second leading cause of death worldwide. Advanced stage cancers often show upregulation of transforming growth factor beta (TGF-β), which suppresses the immune system, induces epithelial-to-mesenchymal transition (EMT), promotes chemotherapy resistance, and facilitates angiogenesis, contributing to tumor progression and metastasis. Current treatment options for advanced stage cancers like triple negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC) are limited and have poor prognosis. Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) worsen prognosis via TGF-β signaling. Inhibiting TGF-β signaling in TAMs and CAFs may offer a potential treatment for advanced cancers. My research focuses on developing TGF-β inhibitory drug conjugates targeting TAMs and CAFs for cancer management.

About Me:

When not in the lab, I enjoy watching movies and web series, spending time with family and friends, and immersing myself in a good book. I love visiting nature spots like beaches, lakes, and mountains for their tranquility. I'm enthusiastic about cricket and soccer, both playing and watching. Photography is another hobby of mine, especially capturing natural landscapes. I also enjoy DIY projects, which let me creatively engage with everyday tasks.