Training Group:

Integrative Neuroscience

Mentor / Lab:

Xi Cheng

Specific Research Area / Project:

Fragile X syndrome (FXS) is a common heritable autism spectrum disorder (ASD) marked by sensory hypersensitivity and learning difficulties. In Fmr1 KO mice, a model for FXS, previous studies have shown impaired 4-8 Hz oscillations, disrupted excitatory/inhibitory (E/I) balance, and short-term plasticity deficits. This study explored how FXS affects inter-areal connectivity between primary (V1) and higher visual cortex (LM). Using silicon probes and channelrhodopsin-2-assisted circuit mapping, we found that Fmr1 KO mice had reduced 4-8 Hz oscillations and weaker synaptic strength in visual pathways compared to wild-type mice. Additionally, visual experience induced dendritic spine plasticity and increased c-Fos expression in wildtype but not Fmr1 KO mice, highlighting the potential therapeutic benefits of visual training for ASD.

Research Profile:

I chose to attend the Purdue University Interdisciplinary Life Science Program (PULSe) because of its unique interdisciplinary approach and the wealth of opportunities it offers. As a member of the integrative neuroscience training group, I appreciate the access to innovative curriculums and diverse research opportunities that span multiple disciplines. PULSe's facilities and resources provide an ideal environment for advancing my research. The program's selectivity ensures a motivated and talented peer group, fostering a collaborative and stimulating academic atmosphere. Moreover, PULSe offers flexibility in shaping my academic journey, allowing me to explore various aspects of life sciences. This comprehensive approach and supportive community make PULSe the perfect place for me to grow as a scientist and contribute to cutting-edge research.

About Me:

I love to immerse myself in creative and calming activities when I'm not in the lab. Playing with Lego allows me to unwind while building intricate structures and exploring my imagination. Additionally, I have a passion for gardening and caring for plants, which provides a peaceful escape and a sense of accomplishment as I nurture my green companions. These hobbies balance my scientific pursuits, offering relaxation and inspiration.